Exact(25)
The juIs76 and wpIs36 integrated arrays were obtained from strains in CGC and outcrossed several times18,38.
In order to test the involvement of PV+ interneurons in CGC, we expressed the light-driven neural silencer Archaerhodopsin (Arch) in these cells using a transgenic approach.
The dealmaking started in October 2017 when it paid $190 million for a 10% stake in CGC.
We measured a CGC-specific dose-dependent increase in production of bile acids in response to increasing cholesterol in CGC media (Figure 3).
In total, 4.76 % of the harmful variations were present in CGC genes.
The proportion of harmful variations is higher in CGC genes (39.88 %) compared to the whole dataset (14.24 %).
Similar(35)
In contrast, TK-deprivation efficiently induced cell death in CGCs expressing c-Jun-wt proteins.
In contrast, cell death was impaired in CGCs expressing the c-JunA95 mutant.
As expected, the c-Jun2-luc reporter was not induced by TK-deprivation in CGCs from c-JunΔN mice.
To this aim, we performed reporter gene assays using a Jun2-luciferase (Jun2-luc) repreviouslyevioushownhown to be induced by TK-deprivation in CGCs.
Notably, the western analysis shown in Figure 2d indicates that c-Jun-wt-HA and c-JunA95-HA proteins have equal steady-state expression levels in CGCs.
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