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Fold change in CFC was calculated by dividing CFC obtained in the presence of a drug by CFC obtained in control conditions.
Interestingly, although we had not identified this MEK1 p.D67N mutant in our CFC cohort, this same MEK1 mutation has recently been reported as a germline mutation in CFC syndrome [29].
This broadly worded "framework" was soon followed by the Montreal Protocol, which called for drastic cuts in CFC usage.
In the upper atmosphere, the chlorine in CFC's acts as a catalyst, destroying ozone molecules.
The SVM classifier in CFC is trained in a similar way.
In CFc this is serious and deserves attention in future work.
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The CFC deficits in the unsaturated zone can be explained by gas exchange with groundwater undersaturated in CFCs.
The initial increase in CFC-11 was likely due to insufficient time to establish equilibrium at time zero between the headspace and liquid phases.
Thus, the efficiency in generating DoxHPC lines directly correlated to the increase in CFCs in EBs.
The increase in CFCs in day 6 EBs when Lhx2 was turned on at day 3 compared to control EBs (Fig. 5F), suggested that Lhx2 expression in intact EBs support self-renewal of hematopoietic progenitor cells independently of exogenously added growth factors.
Perhaps the most challenging aspect in reformulating pMDIs, with surfactants traditionally employed in CFC-based pMDIs and found in FDA-approved products, is the limited solubility in the more polar HFAs [ 7, 20].
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