In case of different subgroups, the most 'normal' subgroup was used for the analyses (for example, if a subgroup of immigrants/military personnel was compared with 'native' civilians, only the latter were used in the analysis).
Non-parametric tests were used in case of small subgroups (Kruskal-Wallis and Wilcoxon tests, respectively).
In the case of subgroup analyses, the threshold was set to P<0.005.
High heterogeneity, due to small number of participants, may also have occurred in the case of subgroup analysis of children.
In the case of subgroup 4 (D3⩽6yr), the disomy 3 status was also confirmed by Multiplex Ligation-Dependent Probe Amplification, as previously described (Lake et al, 2013).
In case of Oryza, this subgroup contains four proteins, which are encoded by three genes, as OsCBSDUF1 gene codes for two proteins whereas, in case of Arabidopsis, this subgroup contains seven proteins, which are encoded by seven genes.
In case of Arabidopsis, this subgroup contains two proteins which are encoded by two genes, while in case of Oryza, two proteins are encoded by a single gene.
In case of Oryza, this subgroup possess 4 genes, which encode for 4 proteins, while in Arabidopsis 5 CBSCBSPB genes encode for 5 proteins.
This is particularly exemplified in case of the hyperdiploid subgroup where one of the original top five discriminators is not present on the HG-U133A array.
The OsCBSCBS4 gene encodes for four proteins through an alternative splicing mechanism whereas, in case of Arabidopsis, AtCBSCBS subgroup contains four genes, which encode four proteins.
