Further, previously developed computational approaches to generate mechanism-anchored gene expression classifiers either failed to produce accurate classifiers as in the case of straightforward median or mean-based gene expression [ 7], or require discrete group assignments of multiple patients in their learning algorithm [ 5, 8].
That day there was one case of straightforward heart disease.
The main benefits of the direct design approach include a reduction of artefacts in case of spectral spatial pulses, a simple and straightforward computer implementation and high flexibility in the pulse design.
In this case the straightforward application of the concept of the basic reproductive number can be of limited usefulness as a key determinant of epidemic dynamics as there is no longer an automatic correlation between <img src="http://journals.plos.org/plosone/article/asset?id=info?doi/10.1371/journal.pone.0012951.e096.PNG" class= inline-graphic"/> and competitive dominance.
Typically, this will be driven by the quest for improved experimental reliability based on repeated runs, or, as in the case of molecular studies, the straightforward need to explore large data sets representing the myriad range of molecular structures.
The effect of mutation in this case is straightforward, as mutations accumulate in each lineage at the mutation rate of individuals in the population (Kimura 1968), thus, we naturally expect that two isolated populations will diverge at twice their mutation rate or 2μ.
Today's mainstream programming environments provide extensibility in straightforward ways: in the case of Java, for example, through the Java Native Interface (JNI) [ 26].
In the case of imports, the interpretation is straightforward.
In the case of SLVMs, the strategy is straightforward.
In the case of the mean, it is straightforward that (48).
