In case of significant changes, the pair wise comparisons were calculated taking the Bonferroni-correction into account.
In case of significant changes in vital signs or clinical status, repeat abdominal imaging was indicated (e.g., ultrasound or CT depending on the clinical condition of the patient).
Participants will be informed about contacting the ECT in case of significant changes in physical or mental health, or in living situations.
Based on the increased rate of VF in AS, imaging of the spine is advocated in cases of significant change in the course of the disease [ 15, 16].
In all cases of significant changes over time – except the awareness of the belt while wearing it (which reached a meanwhile minimum after the fifth week: M = 3.71, SD = .22) – the change was of linear nature (not depicted) with a maximum value after week 1 and a minimum value after week 7, or vice versa.
* significant differences are printed in bold ** effect sizes are only given in case of significant difference Concerning the changes in HRQoL during treatment, we found significant improvements in the KINDLR total score.
Thus, it is of paramount importance to clearly define in the VMP what has to be validated, the extent of validation required for each facility / system / equipment / analytical method, the actions to be taken in case of a significant change (e.g. the replacement of a production / quality control instrument with a different one) together with the conditions for re-validation / re-qualification.
To understand the mechanisms of life-history and size evolution on islands but also in cases of significant body size changes in mainland lineages, histology of hard tissues is a powerful tool, as has been demonstrated for 'dwarf' and 'giant' sauropod [ 10- 12] and tyrannosaurid [ 13] dinosaurs, as well as early synapsids [ 14, 15] among fossil forms.
Of note is the Raza v City of New York case, which was settled this January, having succeeded in prompting a number of significant changes and limitations in mass surveillance practices.
According to the ASAS/EULAR recommendations, imaging of the spine is advocated in AS in cases of a significant change in the course of the disease [ 15, 16].
"In the case of General Motors, a lot of significant changes need to take place," Ms. Mutchler said.
