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We compared the observed data on overlapping genes to a null model that simulates the distribution of expected events in case of neutrality.
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We retrieved overlapping protein-coding genes in 5 representative species (Homo sapiens, Mus musculus, Danio rerio, Drosophila melanogaster and Caenorhabditis elegans), and compared the observed cases with a random distribution expected in case of functional neutrality.
In the simplest case of neutrality, the expected number of recaptures should be proportional to expectations based on the crossings made, x ij.
Essentially the same point has been made by reviewer 3. We now think that it is reasonable to treat a substantial positive correlation as "null-hypothesis", because it is expected in the simplest case of neutrality with some strong selective constraint.
It is immediately obvious from these results that selection constrains tree topology, resulting in more narrow ladder-like trees in each case of selection relative to the case of neutrality.
Austro-German Alliance, also called Dual Alliance, (1879) pact between Austria-Hungary and the German Empire in which the two powers promised each other support in case of attack by Russia, and neutrality in case of aggression by any other power.
On the 31st, when all the other powers had begun preparations of some sort and even the British had put the fleet to sea (thanks to Winston Churchill's foresight), Germany delivered ultimatums to Russia, demanding an end to mobilization, and to France, demanding neutrality in case of war in the east.
The Swiss army decided to abandoned its German-made soldier's pocket knife for a homemade product: it needed a blade, a tin opener and tools for stripping and reassembling the rifle that every trained soldier was made to keep at home in case of an armed threat to Swiss neutrality.
Of course, this neutrality is only valid in case of a single or a few selective events, but not necessarily in a larger timeframe where iterated selection might induce evolution (non-trivial neutrality will be discussed later).
Really?' " If you do read Internet news sites, you would see that Oliver has very quickly become an essential cultural critic, one whose bitterly funny opinion segments on such issues as capital punishment, net neutrality, and payday loans not only respond cleverly to the news but have had a hand in shaping both opinion, and, in the case of net neutrality, perhaps even policy.
In the case of net neutrality, many Republicans find themselves, in this sense, at least, allied to the opposition and ultimately the wrong side of history.
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Justyna Jupowicz-Kozak
CEO of Professional Science Editing for Scientists @ prosciediting.com