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Nonoperative treatment is considered the standard of care in case of grade I and II acromioclavicular joint dislocation, but the treatment of acute grade III is still controversial.
In case of grade 2 neuropathy oxaliplatin was reduced 25%.
Treatment was discontinued in case of grade IV toxicity.
In case of grade 4 hypertension, sunitinib was also discontinued.
In case of grade 3 or 4 allergic/hypersensitivity reactions at any time, cetuximab was discontinued.
Gemcitabine was reduced to 800 mg m 2 in case of grade >2 mucositis.
Vinorelbine was postponed for 1 week in case of grade ⩾3 neutropenia.
Doses of cisplatin were also reduced by 20% in case of grade 2 neurotoxicity.
In case of grade ≥3 somnolence or fatigue VPA will be definitely suspended.
Treatment was stopped in case of grade 4 mucositis, diarrhoea, or hand-foot syndrome.
Capecitabine was reduced with 25% in case of grade 2 hand foot syndrome.
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