Additionally, a lack of effect of NAC on lipid peroxidation in cases of established endotoxemia has been shown [47].
In the presence of fulminant forms of BCS, in cases of established cirrhosis or frank fibrosis, or for patients with defined hepatic metabolic defects (e.g., protein C or protein S deficiency), liver transplantation is the treatment of choice.
In cases of established intracellular influenza A infection, infected cells are mainly eliminated by effector CD8+ T cells (CTLs) (18 ).
Mortality rates from 1%to5%5% are frequently reported for DHF/DSS from centers experienced in fluid resuscitation, but rates up to 44% have occasionally been reported in cases of established shock [ 2].
For highly prevalent risk factors with strong associations with CVD, as in the case of established risk factors, there were strong reductions in absolute risk in each educational category after stratification (i.e., looking at a low-risk population without smoking, hypertension or hyperlipidemia).
In the case of established players for whom little has changed, this is often an inconsequential error.
This is particularly so in the case of established, trusting care-giving relationships where many of the incidents occur in the context of innocuous, even positive parent child routine interactions (e.g., bathing, putting to bed, comforting child).
Given the young age of the affected population, any candidate therapy must be safe and avoid a sustained depression of immune responses thus aiming at inducing or, in the case of established diabetes, restoring immune tolerance to target autoantigens.
In the case of established cancer, a risk biomarker predicts recurrence or progression.
