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In addition, Cmax and AUClast parameters were significantly increased in case of compounds 13 and 14 compared with olmesartan medoxomil.
The presence of –OH groups at either 3 or 4 position of cinnamic acid increased the anticancer activity as see in case of compounds 5 16.
A peak appears at 8 9 ppm in case of compounds (A, A1, A2), which indicates the presence of phenolic OH.
Introduction of lipophilic group on position 5 of the parent was appeared to offer slightly decrease in blood pressure in case of compounds 11 and 12.
Independent solutions of the azonicotinates 8a,c,f (10 mmol) in acetic anhydride (10 mL) were stirred at reflux for 4 h. in case of compounds 11a-c and for 12 h. in case of compound 12.
The compounds having exocyclic substituted phenylenamine ring at C-3 position of the quinolone core showed varying degrees of activities as in case of compounds 5, 7, 15, 16, 17 and 20.
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Highest number of interactions is predicted in case of compound 5d Fig. 7.
Simillarly in case of compound 1 which have glycerol moeity at C-10 significant anti-acetylcholinestrease activity was observed.
The title compounds were obtained in excellent yield and characterized by FTIR, 1H NMR, 13C NMR and X-ray crystallography in case of compound (4a).
The title compounds were obtained in good yield and characterized by FTIR, 1H NMR, 13C NMR, Mass spectral data and X-ray crystallography in case of compound (6a).
The structures of newly synthesized compounds were confirmed by 1H, 13C NMR, mass spectrometry and, in case of compound 18, by single crystal X-ray diffraction analysis.
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