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The title compounds were obtained in good yield and characterized by FTIR, 1H NMR, 13C NMR, Mass spectral data and X-ray crystallography in case of compound (6a).
The structures of newly synthesized compounds were confirmed by 1H, 13C NMR, mass spectrometry and, in case of compound 18, by single crystal X-ray diffraction analysis.
The title compounds were obtained in excellent yield and characterized by FTIR, 1H NMR, 13C NMR and X-ray crystallography in case of compound (4a).
Highest number of interactions is predicted in case of compound 5d Fig. 7.
Simillarly in case of compound 1 which have glycerol moeity at C-10 significant anti-acetylcholinestrease activity was observed.
In case of compound 5p, the NH of N, N-diethylanilinium forms hydrogen bond with Asp86 and stabilizes the complex by the hydrogen bonding.
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In addition, Cmax and AUClast parameters were significantly increased in case of compounds 13 and 14 compared with olmesartan medoxomil.
A peak appears at 8 9 ppm in case of compounds (A, A1, A2), which indicates the presence of phenolic OH.
Introduction of lipophilic group on position 5 of the parent was appeared to offer slightly decrease in blood pressure in case of compounds 11 and 12.
The presence of –OH groups at either 3 or 4 position of cinnamic acid increased the anticancer activity as see in case of compounds 5 16.
The intensity of this peak extremely decreases in case of compounds (A1) and (A2); this may be due to the presence of percentage of unreacted dodecyl phenol in the preparation of the neutral compound.
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