In the case of activating mutations, if the mutant residue is not used by any of the homologues used in the B-SIFT alignment, then the algorithm is unlikely to score the mutation as activating.
Our gene expression profiling revealed that SOCS2 level was significantly higher in AMLs with constitutive STAT5 activation than those without (data not shown), suggesting a negative feedback loop was indeed involved in case of constitutively activated STAT5, rendering those cells less sensitive to further cytokine stimulation.
Since NF- κB pathway is neither activated (important in cases of active infections) nor modulated/suppressed, the formulation appears not to harm immune function.
The number of such tokens was small for example, the number of tokens of associated with and without case sensitivity is 108 and 109, of treated is 327 in both cases, of activated is 82 and 83, of containing is 144 in both cases, and of expressed is 175 and 180.
Somatic mutations in these genes have also been described in sporadic tumours and in the case of GIST, activating mutations in KIT are predictors of response to targeted therapy with imatinib [ 35- 37].
However, it works in case of reactive jammer that activates only when it senses activity on wireless medium.
In case of simulation of the effect of activating a target gene, its expression level values may be increased to the desired value.
Last summer, the federal energy secretary, Spencer Abraham, ordered that the cable be activated in case of a power shortage on Long Island.
Powell's assertion had this "sensitive reporting" basis: "As of Oct. 2002 al Zarqawi was setting up sleeper cells in Baghdad to be activated in case of a U.S. occupation of the city".
The RSS feeds will only activate in case of emergency.
