The early diagnostic procedure was used to make an early assessment of cardiac anatomy and in case of a significant defect to perform early intervention and to prevent pulmonary arterial hypertension in defects with a left to right shunt.
For transfer into novel therapeutic strategies, further questions have to be addressed: in case of a cartilage defect, matrices enabling CPC ingrowth have to be defined.
In case of a substantial bone defect in combination with a poor soft tissue environment, the use of an osteocutaneous free flap is a viable option [ 35– 35].
Furthermore, bone marrow stimulation (for example, the microfracture technique) is not indicated in case of a subchondral bone defect or a loss of bone (osteochondrosis dissecans fragment) [ 27].
However, a spike in Brazil in cases of a birth defect called microcephaly, in which a baby's head is smaller than it should be, raised alarm that the virus might be dangerous for pregnant women and their fetuses.
Soon after it was detected for the first time in Brazil in May 2015, it coincided with a rise in cases of a birth defect called microcephaly, which causes babies to be born with abnormally small heads and underdeveloped brains.
In the case of a defect 50 μm in diameter, defect length does not affect flaking life.
This study demonstrates that BM graft added to MBCP constitute an appropriate material to be considered in case of bone defect occurring in irradiated tissue, and could be foreseen for use after bone removal for oncologic obligations.
In cases of a small-sized defect, the treatment can only be an iliac bone graft.
