In the perioperative context, the balance between thrombosis (in case of anticoagulation interruption) and bleeding (in case of anticoagulation continuation) should be assessed for each patient [ 43].
Parents may opt for a termination of pregnancy and in case of continuation; obstetric and postnatal management can be optimized with referral to a specialized tertiary centre with ECMO (Extra Corporal Membrane Oxygenation) facilities.
As interruption of pregnancy give access to therapies as in a non pregnant woman, the multidisciplinary team have to discuss differences with the patients in case of continuation of the pregnancy.
In case of leucopenia and/or thrombocytopenia, continuation of chemotherapy was delayed until a whole leucocyte count of ⩾3.0 × 10 l−1 and/or a platelet count of ⩾100 × 10 l−1 was reached.
In case of prior outpatient treatment, the continuation of antibiotic treatment on admission was categorised as: no atypical coverage > no atypical coverage; atypical coverage > atypical coverage; no atypical coverage > atypical coverage; and atypical coverage > no atypical coverage.
All this process is re-run until fixed sample size is reached, or in case of fulfilled stopping criteria measuring futility of trial continuation (Zohar and Chevret, 2001).
On that line, it is noteworthy that in the FFCD-9102 trial (CRT for locally advanced EC, then in case of clinical response, patients were randomised between CRT continuation or surgery) [ 33], some patients who were not randomised due to non response, no improved dysphagia, or other reason, were in pCR after subsequent surgery [ 34].
This last continuation procedure fails in case of chattering, and thus it cannot be successful for any arbitrary terminal conditions.
A delay in diagnosis may be deleterious to the patient, whether in terms of unnecessary stoppage of antibiotics in cases of TEC, or inappropriate continuation of offending drugs in CADR.
However, conventional radiology may be the first crucial step leading to suspicion of azygos pathway changes (especially in the case of azygos continuation, haemodynamic changes or catheter misplacement).
The parameter (eta) captures a sufficiently small positive (negative) payment in the case of continuation for (theta > frac{1}{2}) ((theta < frac{1}{2})).
