In addition, broad expression patterns of DNA methyl-transferases (Dnmts) in honey bees that include embryos and the adult nervous system [ 19], suggest that epigenetic controls of genome activities also play important roles in early development and in brain plasticity.
More importantly, our discovery of a sixth splice variant in humans of a PIP5KIγ that is similar to Iγ_v4 and Iγ_v5 in its broad expression pattern [7], but with an apparently different intracellular localisation from those two variants [7], highlights the diversity of potential PIP5KIγ forms, which is in turn probably a reflection of the remarkable diversity of PI 4,5 P2 functions.
The FruMB isoform, like FruMC, shows broad expression in FruM-expressing neurons in the adult male CNS.
The CTAs are attractive targets for developing cancer-specific immunotherapy because of their highly restricted expression in normal tissues and broad expression in a wide range of tumours (Chitale et al, 2005).
Northern blot analysis suggests a transcript ~4 kb in length with broad expression and highest levels in the ovary, prostate, colon and pancreas.
In agreement with this possibility, Dsp null mice display severe blistering more severe in the inner layers in spite of a broad expression of DSP in all layers of the skin (38).
In our study, broad expression also commonly involved CD34 (28 patients), CD10 (31 patients), cCD79a (46 patients), and CD45 (32 patients) (Table 3, Figure 3).
The CK-based gmc680 enhancer trap line was derived in the 14xNTR-Ch reporter background and initially characterized as having broad expression in muscle and in a few sparse neurons within the tectum and midbrain regions.
Nevertheless, the expression breadth of HK genes defined in 18 tissues did show very broad expression in 51 tissues — peaked at about value 42.
