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The known Legionnaires' disease outbreaks in 1999 and 2006 were detected by LRI-clusters, sincluster-signalsals were generated with an increased proportion of patient discharge diagnoses for Legionnaires' disease in both outbreak areas and periods (Table 1, Figure 2a and 3a b) (proportions differed between successive signals: 44 65% in 1999, and 21 63% in 2006; p:<0.0001).
These retrospective studies have been used in both outbreak and non-outbreak settings [ 4- 8].
Mutation of an ABC transporter gene (BCAS0081) upregulated in both outbreak strains, confirmed its role in B. cenocepacia resistance.
Panel 1 genotype 43 made up the most common genotype circulating in this country as observed in both outbreak and sporadic isolates.
Multilocus variable number of tandem repeat analysis (MLVA) has proven to be useful for characterizing the clonal structure of E. coli and other pathogens in both outbreak [ 29] and endemic [ 30] investigations.
In both outbreak investigations, the surveys were conducted among residents >2 years of age, which consisted of an oral interview and collection of 10 mL of blood by venipuncture.
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A report by the European Food Safety Authority said that sprouts grown from fenugreek seeds imported from Egypt in 2009 and 2010 "are implicated in both outbreaks".
In both outbreaks, patients were sickened by the same E. coli strain, called EHEC O104:H4.
And in both outbreaks, the heaviest burden fell on vulnerable populations least able to bear it.
However, in both outbreaks, the prediction error mean is the highest when six days separate the day of data input and the day for prediction (PDD = 6).
Fatalities occurred in both outbreaks.
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