Although no significant interaction can be observed between both moieties in the ground state, after photoexcitation an efficient energy transfer takes place from the PFP backbone to the red chromophore, indeed, by adjusting the polymer/naphthalimide ratio it is possible to obtain single polymers which emit white light to the human eye in solid state.
The copolymer was chosen for its known high performance in OPVs, and both moieties were singled out due to their exceptional resistance to photo-oxidation, an important requirement for such applications.
In the SEA domain, autocleavage takes place resulting in a heterodimer but both moieties remain firmly attached.
The variants containing the F67S, G138D, or V9I plus G138D mutations in addition to the F86Y mutation in both TetR moieties demonstrate an up to 30-fold increased activity at 1000 ng/ml dox.
For example, the variant carrying the F67S and F86Y mutations in both TetR moieties requires only 16 ng/ml dox to reach this 100% activity level, which reflects a 62-fold higher dox-sensitivity than the wild-type sc-rtTA.
For instance, the sc-rtTA with the F86Y mutation in both TetR moieties is ~13-fold more active than wild-type sc-rtTA at 1000 ng/ml dox, whereas the same mutation in the N-terminal or in the C-terminal TetR domain increased sc-rtTA activity ~10-fold and ~3-fold, respectively.
ANP is specific for adenine nucleosides which includes adenosine analogs modified in the aglycone, pentose or both moieties.
Cyclopurine nucleosides are considered tandem lesions in that concomitant damage is produced in both the base moieties and the sugar (Dizdaroglu 1986).
Some of these discrepancies could be explained if the pathways that generated acetaldehyde/ethylene glycol resulted in the liberation of both sulfinate moieties in addition to chloride.
A tricyclic nisin mimic was designed and synthesized in which both thioether moieties were mimicked by an alkane-bridge, as well as the introduction of a third conformational constraint consisting of a macrocyclic lactam-bridge between the N-terminus and the B-ring.
Nucleic acids react with OH by hydrogen abstraction at the sugar or addition to the bases, both resulting in radical moieties and de-polymerization [28, 29, 24].
