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In both methodological approaches we observed rapid TJ protein disruptions after 30 min of oxygen and glucose deprivation or middle cerebral artery occlusion, which were accompanied by strong caspase-3 activation in brain endothelial cells (BEC).
Establishment of comparable research protocols in both methodological and analytical aspects, as well as in selection of patients, is needed to derive conclusions regarding the value of these complex determinations.
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In the area of labour market research in particular, both methodological and content-research studies related to the WageIndicator project (see above) are relatively advanced with respect to testing data representativeness and ways to improve its usability for generalisable research and also allowing comparisons across countries.
In combination, these factors may explain the null finding in women from both methodological and biological perspectives.
In this project, both methodological approaches shall be applied and triangulated.
Repeated measures analysis presents a number of additional challenges to the researcher, in terms of both methodological issues [ 22] and statistical issues [ 11].
When combining studies of this nature for meta-analysis, we assumed that variation existed between trials in both the design and the methodological quality, so we used a random effect model to provide a conservative estimate of the results.
In consequent, the study has both methodological and practical values in knowledge based systems and ship operations modeling.
This study is novel in that it incorporates both methodological and theoretical triangulation into its analytical strategy.
Our discussion extends to both methodological issues in relation to study design and to pragmatic issues relating to the execution of RCTs.
The magnitude of relative risk it conferred in this sample, and the substantial proportion in the population at large, necessitate the identification of potential "hyperfiltrators" in the community which has both methodological and clinical implications.
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