In bold, item-residuals > 2.5 or item χ2 fit with p <.05 corrected for Bonferroni Multiple Comparisons Results described in Table 4 show that 6 items (9, 14, 15, 19, 21 and 22) presented high residuals and/or item χ2 scores significantly different from the expected.
Key: Items in bold = items with low discrimination parameter (< 1.25), = not calculated Thirteen items had all the differences between observed and expected response categories < 0.01, with only one item (I1) having one of the five response differences > 0.01 but less than 0.02.
Key: Items in bold = items with low discrimination parameter (< 1.25).
Key: Items in bold = items with low discrimination parameter (< 1.25), = not calculated Thirty two of the ninety (18 × 5) response categories had a difference between observed and expected response categories > 0.01 with 11 of these having a difference > 0.02.
In examining the nine items in the FKSI-DRS (Table 3, bold items), the differences in means significantly favoured sunitinib (P<0.05) in six of nine items (lack of energy, fatigue, coughing, breathlessness, weight loss, and fever).
DIF contrast in bold indicate items which exhibited differential item functioning A high level of agreement was found between the abbreviated form of the I-QOL and the original version at both baseline and week 12: ICC = 0.900 (CI 95%%: 0.886 0.912) and 0.944 (CI 95%%: 0.936 0.950).
Item in bold text: item deleted after 18 interviews.
(Pain subscale items in bold, sensory/motor symptoms items in italics, specific activity items in underline (SA) and usual activity items in bolde (UA).
Bold items highlighted to illustrate the potential for reduction in unnecessary investigations and inappropriate antimicrobial therapy.
Each item and its origin are in Tables 1, 2 and 3. Items in bold removed by CTT/IRT item analysis Items in bold removed by CTT/IRT item analysis *These items had three categories and were rescaled to a five point scale.
