These data document a substantial longitudinal shift in bloodstream infection etiology in southern Vietnam.
Here we showed that cathepsin K may act as a potent kinin-degrading enzyme in bloodstream.
Staphylococcus was the most frequent organism in bloodstream infection, and enterobacter was the most frequent organism for ventilation-acquired pneumonia.
In contrast, SM was found in both cell stages but they were more abundant in bloodstream forms.
In addition, aggregated proteins are likely to function as immunogenic substances, provoking undesired immune response during circulation in bloodstream.
We investigated trends in bloodstream infections at an infectious disease hospital in Ho Chi Minh City, Vietnam, from 1994 2008.
Functional analysis of the SOD repertoire in bloodstream form parasites was performed using an inducible RNA interference (RNAi) approach.
(1) Vincent JL et al. Rapid Diagnosis of Infection in the Critically Ill, a Multicenter Study of Molecular Detection in Bloodstream Infections, Pneumonia, and Sterile Site Infections.
Diacyl PE are enriched in bloodstream forms compared to procyclic trypanosomes but PG and PS levels were unchanged in both forms of the parasite.
Main pathogens in bloodstream infections were: Staphylococcus aureus (14.25 %), Pseudomonas aeruginosa (9.66 %), Escherichia Coli (9.43 %), Enterococcus faecalis and faecium (8.74 %), Staphylococcus epidermidis, (8.05 %) and Candida albicans (7.36 %).
Furthermore, TSC24 was shown to induce DNA degradation in bloodstream forms of T. brucei indicating that the mechanism of trypanotoxic activity of the compound is topoisomerase II independent.
