The M6P/IGF2 receptor has been shown to be involved in binding, transport and activation of lysosomal enzymes, including cathepsins [ 12, 13].
M6P/IGF2R is also important in activation of TGF-β, a potent growth inhibitor for most cell types, and in binding, transport and activation of lysosomal enzymes, such as cathepsins [ 12, 13].
The identification of highly expressed CSPs and OBPs in the pheromone gland suggests that they may play a role in the binding, transport and release of sex pheromones during sex pheromone production in A. ipsilon and other Lepidoptera insects.
Further experiments will be needed to address the mechanism of cholesterol transport by NPC1L1 and the functions of the different domains in cholesterol binding, transport and internalization.
Similarly, other genes encoding proteins involved in carbohydrate binding, transport, and metabolism were (gbs0032, gbs0033 gbs0035, gbs1416 gbs1417, gbs1914, gbs1916) also expressed at a higher level in donor A blood (Fig. 5 and table S1).
Most of these proteins are functioning in splicing, binding, transport, localization, transcription, translation, and processing of RNA.
We combined the transcriptomic datasets with the E. cautella female sex pheromone precursors characterized through GC-MS studies, identified specifically or highly abundantly expressed genes in the PG and proposed roles for them in pheromone biosynthesis, binding, transport and release.
It was proposed that FATPs and CD36/FAT are the only real transporters directly involved in binding and transport of FAs across membranes.
If F1SBPs are involved in binding and transport of complex oligosaccharides to be used as a carbon and energy source in situ, one would predict that their expression would be induced by the presence of such glycans.
These all had documented roles in binding or transport.
From the analysis of GO terms, we found that the proteins containing octapeptide pairs are mostly enzymes and involved mainly in binding and transport processes.
