Sentence examples for in binding to active from inspiring English sources

Our results indicate that Abi1 might play an additional role in binding to active Rac1 in the complex (Fig. 8A).

Likewise, it was also recently observed that the Lobe 1 (L1) of the FERM domain of Krit1, a region known to fold as a ubiquitin-like domain, is involved in binding to active Rap1.

Inhibitor of apoptosis proteins (IAPs) are a family of proteins that block apoptosis in normal cells, by binding to active caspases, the proteases that mediate cell death.

PABA could compete with DOPA in binding to the active site of PPO.

The molecular docking study revealed that compound 8a was found to the most effective in binding to the active site of E. coli FabH (PDB code 1HNJ) with H-bonding, π-stacking and hydrophobic groove interactions having minimum binding energy ΔGb = −14.00 kcal/mol.

Hence the relative amount of active scFv format in each preparation was also estimated by measuring the fraction of scFv that was active in binding to antigen coated ELISA wells.

Although the 2-carboxy group in 2,4-PDCA and its derivatives is involved in binding to Fe(II) in the active site, 3-amino-4-carboxy pyridines lacking the 2-carboxy group (e.g. 49, Fig. 4) have also been recently described as JmjC inhibitors [130].

It was also argued that a single distal mutation as Ala to Val at the 35th position possibly acts as a trigger to create many other structural rearrangements without disturbing the flexibility of the active site in binding to the substrate [ 61].

For example, in contrast to rice Os3bglu7, Os4bglu12 hydrolyzed β- 1,4 -linked oligosaccharides and laminaribiose at higher rates than pNPG, and did not hydrolyze cellobiose, gentiobiose, pNP-β- 1,4 -linked and pNP-β- 1,4 -linkedde. Their sequence differences are likely toligosaccharidesfferences in substrand binding to the active site between these enzymes.

In addition to binding to the active form, TIMP-1 can complex with pro-MMP-9, whereas TIMP-2 binds to the precursor form of MMP-2 [ 2**].

The ground state structures moreover highlight a striking substrate mimicry utilized by the inhibitors in their binding to the IN active site and suggest ways to improve upon this clinically relevant class of small molecules.