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These compounds spanned a range of structurally different chemotypes with moderate variation in binding affinity.
There was little difference in binding affinity between full length and truncated anti-digoxin D1 aptamer.
Further exploration leads to compounds with greater than 100-fold improvement in binding affinity to p38.
Trehalose induced solution viscosity resulted in significant decrease in binding affinity of BSA towards curcumin and resveratrol.
Surprisingly, rather subtle changes in the structure of NAIR can lead to profound changes in binding affinity.
The increase in binding affinity at lower pH was greater for the Ubx optimal binding site than for other DNA binding sites, indicating that subtle sequence alterations in DNA binding sites may influence pH-dependent behavior.
No difference was observed in binding affinity between any of the age groups studied.
Isothermal Titration Calorimetry will be used to quantitatively assess changes in binding affinity.
The increase in binding affinity of CRP with anti-CRP instigated the increase in R ct.
In binding affinity studies, CGS21680 is 141-fold selective for A2A over A1 receptors [33].
In particular, the Tyr-to-Ala mutation at position 313 resulted in a merely two-fold reduction in binding affinity.
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