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However, the extent and specificity of this proposed activity of SbEhd1 will require further analysis in backgrounds where SbCO has minimal influence on the expression of these genes (Sbco-3 backgrounds).
Under these conditions septation is normally prevented, however, in backgrounds where the activity of Cdc2p is reduced, cells are competent to form septa despite their failure to exit mitosis.
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In the second approach, we examined toxicity of Aβ in genetic backgrounds where copper transporter genes were mutated.
We observed fog-1 reporter derepression in the backgrounds where one of two fbf genes was mutated, but rarely in the wild-type background worms subjected to splicing factor RNAi.
Age-specific mortality plots are in agreement with left-censored survival results, with low aging-related mortality in all backgrounds where lifespan extension is significant (Fig. S4A and S6A C).
Genetic experiments argue that the more stably associated TLC1 reflects active telomerase, as these associations are less frequent in genetic backgrounds where telomerase recruitment is impaired.
Importantly, miRNAs which are unrelated in sequence may function in concert as demonstrated by the phenotypes of individual miRNA mutants, which are revealed only in genetic backgrounds where miRNA levels are globally reduced [ 26].
In contrast, efficient repair of subtelomeric DSBs may require telomere localization at the periphery as such breaks within the XI-L telomere are less often repaired in genetic backgrounds where telomere tethering is lost (Therizols et al. 2006).
Prohibitin depletion results in reduced fat content, in all genetic backgrounds where PHB deficiency extends lifespan [ 17].
The shots that slipped past my defenses were common snapshots done in the all-American tourist style, with someone standing stiffly in the foreground and, in the background, where Mount Rushmore should be, two partially demolished tall buildings in flames.
In BL31, EBV is operating in a background where various signalling and transcriptional pathways are likely to have been distorted during oncogenesis and cell line outgrowth, most notably the constitutive activation of the c-Myc oncogene characteristic of BL.
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