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Decreased S100A4 expression may result in attenuation of migration and invasion abilities.
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Here we demonstrate that mouse retinal PCs not only exhibited higher rates of apoptosis, as shown in PCs from other species, but also exhibited attenuation of migration under high glucose conditions.
The decrease in viability of <10% at each time point is unlikely to account for the 56.8% attenuation of invasion and the 60.82% attenuation of migration.
siRNA targeting of STAT3 resulted in attenuation of the enhanced cardioprotection of TLR4-deficient MSC.
This results in attenuation of the pro-apoptotic effect of LMP1, which ensures cell survival [28].
Interestingly, the triggering of TLR3 by dsRNA can result in attenuation of the TLR4 pathway [54].
Tissue response results in attenuation of the input signal.
Thus, our results demonstrate that attenuation of PU.1 expression by HDAC inhibition causes reduced expression of key DC regulators, which results in attenuation of DC development.
The difference might be due to the decrease in cell proliferation and/or the attenuation of cell migration ability, which was proved in our study.
Complement has been linked to oxidative stress and PMN activation in models of sepsis and inhibition of complement activation resulted in reduced ROS production and attenuation of PMN migration and activation to the site of injury [ 91, 92].
The DCN-provoked inhibition on the PDGF-dependent phosphorylation of the PDGF receptor results in the attenuation of cancer cell migration [ 19, 55].
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