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The very small Pt nanoparticles in reduced Cs-overloaded Pt/Cs-BEA are particularly active in aromatization of n-hexane.
A new method to modify the acidity of zeolite was attempted to improve the activity and stability of Zn/ZSM-5 in aromatization of 2-methyl-2-butene.
XPS, EXAFS, H2-TPR, NH3 TPD and TPD-IPA (temperature programmed desorption of isopropylamine) were employed to investigate the active species of Zn in aromatization of glycerol.
Thus improvement of lifetime of Zn/ZSM-5 in aromatization of 2-methyl-2-butene was achieved without deteriorating activity and selectivity by the pre-coking and controlled regeneration by oxygen.
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Interestingly, when letrozole and anastrozole were compared in the same patients in a crossover study [ 58], letrozole was found to be a more potent inhibitor of in vivo aromatization in all patients; subsequent plasma estrogen analysis also revealed that letrozole treatment resulted in significantly better suppression for each estrogen fraction [ 37].
The catalytic behavior of Mo-IM-5-S, Mo-IM-5-M, and Mo-IM-5-C catalysts in methane aromatization is shown in Fig. 5.
The band at 1502 cm−1 represents aromatics being intermediates in the aromatization of methanol.
In vivo studies demonstrated letrozole to be significantly more potent than anastrozole in inhibiting total body in vivo aromatization (Geisler et al. 2002) and suppressing breast cancer tissue estrogen levels (Geisler et al. 2008 b ).
Using this method, we systematically classified different aromatase inhibitors (Jones et al. 1992, Lønning et al. 1991, MacNeill et al. 1992, 1994, 1995, Geisler et al. 1996 b, 1998, 2002) based on their efficacy in inhibiting total body in vivo aromatization (Table 1).
Aromatase (CYP19A1) is a key enzyme in the synthesis of sex hormones and is involved in the aromatization of androstenedione to form estrone (E1) and of testosterone to form 17β-estradiol (E2).
While in vivo tracer injections provide the 'gold standard' when measuring in vivo aromatization and the endocrine efficacy of different aromatase inhibitors, the method is time- and source-consuming and may be applied on a limited number of patients for research purposes only.
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