Sentence examples for in apl from inspiring English sources

Using PML/RARA transgenic mice, we investigated whether PML RING tetramerization is important in APL development.

Collectively, these data establish the requirement of RING tetramerization in APL development in vivo and arsenic response ex vivo.

To overcome these major drawbacks, we used a deductive approach which involved modifying proteolytic cleavage sites in APL.

However, it is not clear whether additional chromosomal abnormalities in APL patients directly influence the prognosis or treatment response.

ATRA specifically targets the transforming potential of the fusion gene product, PML-RARA, commonly detected in APL.

Specifically, the promyelocytic population showed partial positivity for antigens not usually expressed in APL (HLA-DR and CD117).

The combined use of pharmacologic differentiating agents and growth factors may improve the clinical efficacy of differentiation therapy in APL.

Previous studies demonstrate that the combination of all-trans retinoic acid (ATRA) works better than AS2O3 alone in APL treatment.

Following further investigation, we found an unexpected behavior in APL curve design which led to the latency occurring only in particular scenes that affects some users.

Probesets with an FDR below 0.05 were considered to be differentially expressed in APL compared to AML.

These findings suggest that the control of G-CSF responses by the antioxidant protein PRDX4 may be perturbed in APL.