How evidence was gathered and the scientific grounding of recommendations were not explicit in any guideline.
Axillary lymph node dissection (ALND) has not been recommended in any guideline since 1992 and the administration of tamoxifen or other hormonal therapy has not yet been advised.
For none of the recommendations based on a mixed population it could be assessed if the study setting influenced the outcome, nor was this difference discussed in any guideline.
10 In any guideline elaboration, it seems important to base treatment decisions on biological age and not chronological age; we are not equal in terms of aging – physiological, social, and cognitive changes can appear and they are specific to each individual.
If the race is not run in waves, read any guidelines about start-line etiquette.
A recent systematic review of guidelines for limiting bias in preclinical research design was unable to identify any guidelines in oncology (Henderson et al., 2013).
For example, the statement (in the Introduction) "A recent systematic review of guidelines for limiting bias in preclinical research design was unable to identify any guidelines in oncology (Han et al., 2013)" is not supported by Han et al., 2013.
An additional consideration in the development of any guidelines should be the severe shortage of health workers in African LMICs, a circumstance that, at present, makes it impossible to provide the level of monitoring required for septic patients [ 10].
However, it cautioned that "there is little evidence regarding the impact of any guidelines in changing health behaviours".
