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Still, there are two major obstacles for MALDI MS in analysis of small molecules, including (1) selection of tailored matrix materials for specific application with high efficacy; and (2) quantitation of analytes overcoming the non-predictable desorption/ionization behavior [15, 17].
It is also especially useful in analysis of small tumour samples.
Elementary flux modes have proven to be useful in analysis of small to medium-scale metabolic models [ 28].
The essay by well-known Hungarian mass spectrometrist Károly Vékey describes selected applications of mass spectrometry in analysis of small biomolecules, developed mainly by scientists from Central and Eastern Europe.
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Compared to previously reported methods, it has distinct advantages of in-depth analysis of small RNA populations and the ability to identify novel microRNAs (Creighton et al., 2009; Fahlgren et al., 2009; Tam et al., 2014).
The ~3.8 mm depth range achieved with our present instrumentation enables the in-vitro analysis of small animal bones, for example, mouse bones.
The authors provided an in-depth analysis of small RNA profiles of six different tissues (spleen, liver, brain, testis, heart, kidney) of two different rat strains (BN-Lx and SHR) [ 33].
Here, we provide an in-depth analysis of small RNA DGE profiles from two different rat strains (BN-Lx and SHR) from six different rat tissues (spleen, liver, brain, testis, heart, kidney).
The recent advances in ICD reagents for carboxyl, amino, carbonyl, thiol and hydroxyl groups and their applications in the analysis of small molecule metabolites in bio-matrices with LC-MS/MS were reviewed.
Accordingly, the non-linear formulation presented in this paper can be used in the analysis of small as well as large deformation.
This paper is the first part of the presentation of a chemometric approach for the rapid selection of a suitable background electrolyte (BGE) in CZE analysis of small drug molecules.
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