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The effect of receptor expression was also examined in an aggregation assay where cells are prevented from adhering and form aggregates in suspension.
These results indicate that the N-terminal portion of TDP-43 fulfills an important role in an aggregation context by mediating the interaction between endogenous TDP-43 and the aggregates.
Alternatively, aggregator A j and disseminator D i have been involved before in an aggregation session with a different selected state.
In an Aggregation, one company–like Wal-Mart usually leads in hierarchical fashion, positioning itself as an intermediary betWal-Mart usuallynd customers.
This mutual membership check detects an exploitation outcome in an aggregation session if and only if M D i A j ⋒ M A j D i : negative.
Duplicate: Aggregator A j and disseminator D i have been involved before in an aggregation session with the same selected state.
Similar(41)
The experiment of grafting of healthy neurons with unhealthy neurons possessing a-Syn aggregates can result in a-Syn aggregation in previously healthy neurons [ 28, 29].
However, the N-terminal fragments impair neurite growth in an aggregation-dependent whereas the C-terminal fragments impair neurite growth in an aggregation-independent manner (Fig. 5, 6).
Once aggregation-enabled, however, the N-terminal fragments can impair the neurite growth in an aggregation-dependent manner.
Thus, it is conceivable that the C-terminal fragments can impair neurite growth in an aggregation-independent manner.
By flow cytometry, we observed a pattern of YOPRO-1 staining that exactly paralleled our PI results, as the cellular toxicity of mutant httex1-72Q increaned in aggregation-specificfic manner with scFv-6E intrabody but was completely suppressed upon blocking aggregation with scFv-C4 intrabody (Fig. 7C).
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