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In an adequately insulated home, the temperature is constant throughout each room and walls, ceilings and flooring remain warm in the winter and cooler in the summer months.
However, these early findings of efficacy in symptom amelioration should be replicated in an adequately powered, randomized, placebo-controlled double-blind design.
The development of smart materials, mainly based on biopolymers and bone-like calcium phosphates, appears to provide an attractive alternative for delivering BMPs in an adequately controlled fashion.
Whether restoring and maintaining sinus rhythm will have a beneficial impact on cardiovascular mortality in patients with heart failure has never been tested in an adequately powered randomized trial.
Recent mechanistic and clinical data suggest that higher loading and maintenance doses of clopidogrel may achieve a more rapid and greater degree of platelet inhibition that translates into improved clinical outcomes, but this is yet to be formally evaluated in an adequately powered randomized trial.
The utility of oral anticoagulant and/or antiplatelet therapy has never been evaluated in an adequately powered dedicated clinical trial of HF patients in sinus rhythm.
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The estimation of an effect size is an important step in designing an adequately powered, feasible clinical trial intended to change clinical practice.
In particular, "an adequately powered trial should be conducted to investigate the clinical and cost-effectiveness of arts therapies as compared to an active control in people with schizophrenia" [ 1] (p200).
The direct payment of £5 significantly increased the completion of postal questionnaires within our trial in primary care at negligible increase in cost for an adequately powered study.
The direct payment of £5 significantly increased the completion of postal questionnaires at negligible increase in cost for an adequately powered study.
In addition, MRI revealed only minimal free fluid in the abdomen, demonstrating an adequately functioning draining device.
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