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However, using nonmammalian species in alternative test strategies may help address some of these behavioral end points.
The relevance of the TCLP for arsenic leaching tests was brought into question by data that compare arsenic leaching rates in alternative test methods, including methods that are designed to simulate chemical and biochemical conditions in sanitary landfills (Ghosh et al. 2006b).
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This paper reviews the potential of invertebrates in testing environmental chemicals and provides evidence of their usefulness in alternative testing methodologies.
The Embryonic Stem cell Test (EST) is an in vitro alternative test designed for the prediction of embryotoxicity.
The ultimate challenge for developing non-animal test methods for skin sensitization testing will be applying our mechanistic understanding of ACD to the design of predictive in vitro alternative test methods.
The ultimate challenge for developing non-animal test methods is applyied in the mechanistic understanding of contact allergy and ACD to the design of predictive in vitro alternative test methods.
ICCVAM's focused efforts have resulted in approved alternative test methods for many types of product safety testing, including the four most commonly conducted safety tests: acute oral toxicity, dermal irritation/corrosion, ocular irritation/corrosion, and allergic contact dermatitis.
In an alternative test of the independence of the effects of AluY insertions and the recombinogenic motifs that sometimes occur in them, we generated subsets of the HapMap data by removing all AluY regions where the focal AluY contained either recombinogenic motif.
It could also help in the acceptance of the current screening as an alternative test in cases where NIPT does not provide a result in first line screening.
A first step would be to refine the current in vivo strategies by integrating information derived from in vitro and nonmammalian alternative test strategies.
According to Birnbaum, this agreement and other recent advances in the field have brought about substantial progress in the development of alternative test methods.
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