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Malalignment and instability, resulting in alteration of loading of the articular cartilage, initiates complicated biochemical pathways, leading to matrix degradation.
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Moreover, Once degeneration sets in, the intervertebral disc goes through a cascade of degenerative changes that result in biomechanical alteration of load transfer through the disc.
It has been theorized that patients with PFPS exhibit altered movement patterns in the lower extremities that may result in alterations of the load distribution across the patellofemoral joint [ 1, 21, 34].
Trabecular bone loss in the vertebral bodies may, in addition, be enhanced by local inflammation and alterations of loading due to syndesmophytes and ankylosis.
Similar to results with flecainide, application of TTX at this concentration resulted in no significant alteration of SR load.
An alteration of the loading direction, e.g. can occur either occasionally paired with an overload (mixed mode overload) or permanently in terms of a mixed mode block loading as a combination of normal and shear stresses.
It remains to be tested whether miR-146a is responsive to alteration of mechanical load in addition to proinflammatory cytokine.
INTERPRETATION: Alterations in cyclical loading of tendon may cause a change in fibroblast-mediated inflammatory mediator production in tendon.
Little is known, however, about the role of calcineurin in response to acute alterations in loading conditions of the heart, where it could be mediating beneficial adaptational processes.
In this paper we considered the different loading conditions of the young and old lumbar spines mainly caused by disc degeneration and studied the effect of loading alteration on trabecular architecture in lumbar spines.
Haemodialysis represents an unparalleled model of abrupt alteration in LV loading conditions.
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