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Because proteins and other molecules with a high polyphenol content are commonly involved in adhesion processes, we are investigating the interactions between polyphenols and biological materials.
Taken together, these observations suggest prohibitins play a crucial role in adhesion processes in the cell and thereby sustaining cancer cell propagation and survival.
Sialoadhesin mediates cell-cell interactions by recognizing Neu5Acα2,3Gal in either N- or O-glycans on the surface of several leukocyte subsets [3], [6], suggesting that sialoadhesin could be involved in adhesion processes.
The Hsf autotransporter homolog, thought to be important in adhesion processes, as well as pga genes necessary for biofilm formation, were not identified either.
GPR56, downregulated in all the three contrasts, is a G protein-coupled receptor involved in adhesion processes that participates in cytoskeletal signaling, cellular adhesion and tumor invasion.
Two other types of domains were commonly identified in all the rtx genes: the VWA domain involved in adhesion processes [ 32, 33], and another tandem repeated domain related to cytotoxic activity, the haemolysin calcium-binding (HemolysinCabind) site.
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These proteins were not included in the training set due to absence of evidence on their direct involvement in adhesion process.
The flocculins are involved in adhesion process in S. cerevisiae [ 56, 57] and therefore it is probable that these proteins have functional similarity in their role as adhesins in C. glabrata as well.
In physiological circumstances, ALCAM is involved not only in cell adhesion processes, but in neurogenesis, hematopoiesis, and immune responses as well [ 27].
Besides these terms, the analysis result of SCLC shortest path genes showed that they were significantly enriched in cell adhesion processes, suggesting that genes in this term might play an important role in differentiating SCLC from NSCLC (see additional file S6).
As mentioned before CRT is also involved in the ER processing pathways in addition to its role in cell adhesion processes.
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