The role of 5-HT in these different respiratory pathologies has not been fully investigated; however evidence is emerging that it can be secreted locally by many different cell types and in addition to its powerful vasoactive effects on pulmonary arteries, 5-HT can stimulate the proliferation and fibrogenic actions of lung (myo)fibroblasts [47,48].
In addition to the biological functions of CO under physiological conditions, the substantial contribution of CO to the protective effects of induced HO activity has recently been recognized and includes vasoactive, anti-oxidative, anti-inflammatory, anti-apoptotic, and anti-proliferative properties.
Thus, as demonstrated here, the action of Semax on the expression of genes that ensure the formation and functioning of the vascular system in ischemic conditions also uncovered its possible vascular and regenerative properties, in addition to its neuroprotective and vasoactive effects.
4 In addition to its vasoactive properties, BK plays a role in renal cell growth and proliferation.
It is a neurotransmitter/modulator in addition to its vasoactive function in all mammalian species [ 3, 4].
All patients received inotropic support in addition to other vasoactive drugs, as clinically indicated, and fluid therapy by using crystalloids and colloids.
In this multicenter, double-blind trial, children with clinical evidence of vasodilatory shock were randomized to receive either low-dose vasopressin (0.0005 to 0.002 U/kg/min) or placebo in addition to open-label vasoactive agents.
Aim: To investigate the influence of ciclosporine A (CsA) on the vasoactive effects of serotonin in human umbilical arteries.
However, the vasoactive effects of H2S in the fetoplacental vascular bed remain unexplored in any species.
Despite conservation of the vasoactive effects of NO in the zebrafish (North et al., 2009), it was found not to be the mechanism of action for liver modulation.
