Thus, in addition to the initiating mutations, somatically acquired genetic and epigenetic changes may distinguish CTCs derived from different tumors.
Loss of p53 checkpoint function can lead to genomic instability and, in addition to the initiating virus-driven events, cervical carcinomas accumulate multiple genomic changes, of which only some are driver mutations for tumour development (Allen et al, 2000; Lando et al, 2009).
In addition to the effects initiated at the plasma membrane, G protein-coupled receptors (GPCRs) may also trigger signaling cascades upon their activation within the cell.
In addition to the care directly initiated by the hospital or inpatient rehabilitation service, they referred patients and caregivers to speech therapists (N = 11), occupational therapists (N = 9), physiotherapists (N = 8) and sometimes a dietician, social worker or psychologist (N = 28).
In addition to the molecular consequences of initiating mutations, the gene expression profiles of metastatic cells may be influenced by their supporting microenvironment in target organs (Nakamura et al, 2007).
For elderly patients without established CVD, the NCEP relied on additional data from PROSPER and ASCOT to recommend the use of clinical judgment in addition to the Framingham risk score for initiating lipid-lowering therapy.
In addition to the government's attempt to initiate a crackdown on migrants using the train, the train company's private owner, Ferrocarriles Chiaplansayab, plans to make significant investments to improve the railway itself so that the trains may operate at faster speeds, which they hope will help deter migrants from hopping onboard.
In addition to the diverse pathways that accurately initiate heterochromatin assembly, anti-silencing activities also play essential roles in limiting heterochromatin spreading to shape the chromatin landscape.
In addition to the binding of uPA, uPAR initiates signal transduction pathways by interacting with other molecules such as vitronectin, integrins β1/2/3, cytokeratin 8/18 and EGFR (epidermal growth factor receptor) [ 1, 20].
In addition to the core epigenetic proteins that initiate, modify and act upon epigenetic modifications as described earlier, there are a range of borderline cases, in particular because these core proteins are part of large networks of gene regulation and complex formation (i.e. through protein protein interactions).
Download all the rooting files for Tab 4, in addition to the ODIN file that will initiate the rooting process.
