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In addition to the deletion of RGA1, 44 other gene models were predicted to be deleted in the d1 mutant line at log ratio ≤ -0.8 for 50% or more of probes.
In addition to the deletion, a single amino acid change at position 79 (P79S, numbering based on the WT702 virus) was also observed in the NA of the adapted viruses.
In addition to the deletion of the E1B55k gene ONYX-015 harbours a deletion of the E3B region, which contains the gp19k gene that is able to inhibit MHC class-I antigen presentation at the cell surface.
In addition to the deletion, a de novo nonsense mutation, R525X, was found in the FOXP1 forkhead domain in another patient with non-syndromic intellectual disability (IQ of 48), severe language impairment and ASD.
In addition to the deletion of NEU3 activity, the present data provided evidence that NEU3 silencing reversed the malignant phenotype, probably due to accumulation of GM3, as evidenced by results of the experiment with exogenously added GM3.
By taking regulatory effects into account, OptORF can propose changes such as the overexpression of metabolic genes or deletion of transcriptional factors, in addition to the deletion of metabolic genes, that may lead to faster evolutionary trajectories.
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In addition to the deletions common for the Beijing and ST42 isolates, the presence of an extra region, MT1360, distinguished the ST42 isolates from other non-Beijing isolates.
In addition to the deletions associated with type-A insertions and vice versa, we also found 473 type-B insertions associated with deletions in the Hawaiian genome.
In addition to the deletions associated with intron loss, the S. noctiflora and S. conica plastid genomes have also experienced a total of 10 and 11 large indels of >100 bp in size, respectively.
After excision with the Cre recombinase, in addition to the 16p deletion, a mosaic trisomy in chromosome 5 was observed (See Table 1 and Supplementary Fig S7).
Hence, we hypothesize that mutation of the gene in S19, in addition to the large deletion in the eryABCD operon, further contributes to the inability of S19 to metabolize erythritol.
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