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In addition to the activation signature, additional miRNAs are differently expressed in CLL compared to untransformed B cells.
In addition to the activation of several different apoptosis regulating pathways doxorubicin activates also pathways that activate proliferation, differentiation and inhibition of apoptosis.
During physiological stress, the activated immune system secretes pro-inflammatory cytokines in addition to the activation of NADPH oxidase and generation of reactive oxygen species.
In this study we further investigate the mechanisms of cell death induced by DT-GMCSF and show that, in addition to the activation of caspase-dependent apoptosis, DT-GMCSF also kills AML cells by simultaneously activating caspase-independent necroptosis.
Current evidence suggests that immunotherapy for cancer or infectious diseases will require the activation of CD4+ T cells in addition to the activation of cytotoxic CD8+ T cells.
These findings indicate that in addition to the activation by NQO1, the oxidative stress presumably initiated by single-electron transferring enzymes may be an important factor in the cytotoxicity of aziridinylbenzoquinones.
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This observation opens up the possibility that in addition to the host activation, B. anthracis-bound PLG may be activated by a bacterial activation system such as pro-uPA activation by bacterial proteases.
In addition to the common activation of SOFC, there were activations that were particular to each category of visual stimulus (Fig. 2).
Using a mixed 2 (group: ACT, Control)×2 (condition: wins, losses)×2 (time: pre, lost) design, the self-report and behavioral aspects of the slot machine activity, in addition to the brain activation data were compared across time.
In addition to the increased activation in various regions, analysis revealed decreased activation in the CM-Group in anterior cingulate regions compared to the controls.
Our results indicate that, in addition to the endothelial activation, enhanced platelet reactivity, as caused by the thrombin activation, may contribute to the acceleration of microvascular thrombus formation in endotoxemic animals.
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