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In addition to stimulation of proP P2 transcription by Fis, CRP co-activates this promoter when bound to a remote site upstream from the promoter (centered at −121.5).
We have shown previously that, in addition to stimulation of collagen I expression, aldosterone increases PCPE-1 expression in cultured heart fibroblasts.
Investigating the impact of different MC1R variants on the response of human melanocytes to UV led to the important discovery that the MC1R signaling activates antioxidant, DNA repair and survival pathways, in addition to stimulation of eumelanin synthesis.
Therefore, RUNX3 may be involved in allowance for high cell density in addition to stimulation of cell growth.
In addition to stimulation triggered by Wnt8, β-catenin participates in the suppression of vertebrate Vent genes in dorsal lip at early stages of development.
In addition to stimulation by IGFs, the PI3K/AKT/mTOR pathway has recently been shown to be nutritionally regulated, in that mTORC1 phosphorylation is dependant on amino acid availability [23].
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However, several reports have demonstrated that full activation of p38 MAPK in vitro requires co-stimulation in addition to TCR stimulation.
Additionally, the increase in new blood vessels may have supplied nutrients and growth factors for the stimulation of cell-cycle progression in addition to the stimulation of metastasis.
In addition to potential stimulation of iBREC proliferation, possible additive effects of the growth factors were investigated.
The application of inflammatory substances on the dura mater, in addition to chemical stimulation of the dural receptive fields, cause hypersensitivity to mechanical and thermal stimulation, as well as activation in the TG and in brain stem trigeminal neurons, similar to what could be expected in migraine [17, 24].
In addition to the stimulation of insulin release, GLP-1 also inhibits glucagon release and stimulates somatostatin secretion [ 10].
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