The position of these clusters is expected to vary with the number of non-segregating subgenomes that are targeted in addition to the segregating subgenome.
In addition to the expected segregating genomic CNVs, 124 de novo CNVs were identified (Table 1): 64 singleton, and 60 recurrent in which the same or similar breakpoints were called in at least 2 progeny.
In addition to the scarcity of segregating sites in the D. melanogaster mtDNA, polymorphisms at these sites were skewed toward low frequencies, as evidenced by consistently negative values of Tajima's D (Table 1).
Four of the small allied/segregate genera are embedded within the clade of the Artemisia-group, in addition to the large segregate genus Seriphidium (Fig. 1).
The GasGBLUP schemes require that knowledge on both the exact position of the target QTL and its effect exists prior to the selection experiment, in addition to a dense marker map including segregating marker loci for both populations.
While there were only 9 single nucleotide polymorphisms (SNPs) in TvPirin (Additional file 6, Table 2), TvQR1 contained 350 segregating sites in addition to 31 insertions/deletions (indels) throughout the entire gene body, with indels present only in introns, and with the highest diversity in intron 3 (Additional file 5, Table 2, Figure 3A).
In addition to classical phenotypic QTL information from segregating populations, QTLs may also be resolved through association mapping of targeted candidate genes, based on an assumption that the allelic polymorphism of the gene is associated with the variation of the trait and provided that linkage disequilibrium is sufficient [ 59].
In addition to PTP1B, TCPTP is also spatially segregated from PM-localized EGFR by its association with the ER and has been shown to dephosphorylate Y845 (Mattila et al., 2005).
This genome panel system has been applied to linkage analysis of >10 segregating populations in addition to the three populations analysed in the present study, and it has successfully built the framework of each linkage map (data not shown).
In this experiment, he discovered a number of phenotypic variants, which bred true or segregated variant types in addition to the parental type.
