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Notably, Garcia-Maceira et al. [6] reported that silibinin was more effective in inhibiting HIF-1α accumulation than rapamycin, which suggests the participation of an additional mechanism in addition to repression of the mTORC1/4E-BP1 pathway.
In addition to repression of translation by uAUGs, additional regulation of mRNAs containing uORFs can be brought about by the uORF affecting transcript stability.
Starting in the twentieth century, in addition to repression that impacted individual Bahá'ís, centrally directed campaigns that targeted the entire Bahá'í community and its institutions were initiated.
In addition to repression of several specific mRNA targets, overexpression of ArcZ results in differential expression of over 750 genes and loss of motility [ 55].
In addition to repression these first studies also explored the role that dCas9 could play in activation (CRISPRa) by introducing a dCas9 fused to the RNA polymerase ω subunit capable of causing up to 23-fold increase in expression [ 22].
In addition to repression of the genes involved in carbon metabolism noted above, inactivation of Snf1 unexpectedly results in induction of dozens of genes involved in amino acid metabolism regulated by Gcn4 (Shirra et al. 2008; Zaman et al. 2009).
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In addition to its repression by RUNX1 in ER+ luminal MECs, we found Elf5 is repressed by RUNX1 in almost all other MEC subsets (including basal MECs) in which Runx1 is expressed.
It is interesting to note that, in addition to the repression of RASSF5 expression by promoter hypermethylation, yet another unknown mechanism may downregulates RASSF5 function in cancer cells.
In addition to the repression of metamorphic genes and tissue competence, the premetamorphic TR may also contribute to tissue sensitivity/responsivity.
In addition to translational repression, CGH-1 and GLD-1 (an RNA-binding protein) also mediate mRNA stabilization in nematode oocytes (65).
However, TH17 cells stimulated with IL-12 exhibited higher levels of H3K4me in the infg loci, in addition to H3K27me3 repression of il17a and il17f loci.
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