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Therefore, nutrient depletion likely induces DNA damage in addition to replication stress.
This suggests that nutrient depletion induces DNA damage, in addition to replication stress.
In addition to replication studies, we are also conducting a microarray gene expression study to examine the mRNA-level transcriptional difference of the identified genes.
In addition to replication stress-induced breaks, loss of Hdacs1,2 also impairs double-strand DNA break repair [ 27].
In addition to replication of these findings specifically, human studies such as pharmacologic intervention trials may further understanding of these potentially modifiable genetic pathways.
More direct evidence comes from analysis of NM attached DNA, by 2D agarose gel electrophoresis, which revealed termination structures in addition to replication intermediates.
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So far research has emerged from three countries (Canada, New Zealand, the U.S ., involving scientists at multiple academic institutions, in addition to replications by clinicians in their private practices; none of the studies have been financially sponsored by the company.
Slightly more than half of all apoptotic oligodendrocytes were reactive for viral nucleocapsid, suggesting additional complex apoptotic mechanisms in addition to JHMV replication, perhaps through glutamate excitotoxicity [49], as viral infections or cytokine stimulation of astrocytes abrogates in vitro glutamate uptake [50] [52].
Figure 3 shows that inhibition of replication affects many other proteins in addition to the replication proteins of clusters I1, 2, and 3.
This revealed an unexpectedly broad system-wide effect on the chromatin proteome, indicating that the response to replication inhibition extends to many other functional modules in addition to the replication machinery.
In addition to frequent replication pauses at the 5′ and 3′ ends, Koike and Wolstenholme [ 36] point out that mtDNA replication is a discontinuous process.
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