In addition, the use of polymeric antimicrobial agents have the advantages that they are nonvolatile, chemically stable, and find it difficult to permeate through the skin of man or animal and may enhance the efficacy of some existing antimicrobial agents and minimize the environmental problems accompanying the residual toxicity of the agents in addition to prolonging their lifetime [2, 11 14].
We find that, in addition to prolonged mitotic arrest, there are chromosome segregation defects, micronuclei formation and genomic instability.
In rats, DEHP exposure decreased the levels of estrogen and progesterone (Svechnikova et al. 2007) in addition to prolonging menstrual cycles and anovulation.
The use of such combination of clonidine and meperidine in these doses avoids the occurrence of hemodynamic instability such as hypotension and bradycardia in addition, to prolonged postoperative analgesia.
Corresponding physiological findings have been replicated in WT murine hearts in which increased slowly inactivating late Na+ current components produced by the sea anemone Anemonia sulcata toxin increased CLs, PR intervals, and SNRTs in addition to prolonging electrocardiographic QT intervals and resulting in ventricular tachycardia.
In addition to prolonged physical or mental fatigue, qualitative research has also identified personal problems such as cognitive limitations, difficulty mobilising support, difficulty managing stress and anxiety, difficulty coping with a new self image, and changed attitude to work [ 24, 31- 34].
Therefore, treatment should aim to improve palliation, quality of life and symptom improvement in addition to prolonging survival.
In this context, the aim of anti-cancer treatment is to improve or maintain quality of life (QOL) in addition to prolonging survival.
In inoperable advanced second-line NSCLC, active treatment is well established in Spain and achieves both palliation of symptoms and improvement of QoL in addition to prolonging survival.
