Although Oct-4 was previously suggested to be a limiting factor during the procedure of isolation of rat ES cells [14], it appears that in addition to its function as pluripotency factor, it might have a role for the self-renewal of rat XEN cells.
It has been reported that in addition to its function as a DNA replication initiator protein, it also plays a key role in transcriptional gene silencing and heterochromatin formation [8].
Further clarification of the important issue whether the TA of classical TA proteins is, in addition to its function in membrane anchoring, of other functional significance, requires appropriate assays that assess protein activity in response to alterations of the TA.
It is now clear that in addition to its function as a transcription factor of pro-apoptotic genes, post translational modifications of p53 also plays a direct role in mitochondrial mediated apoptosis [40], [41].
The nucleolus plays several crucial functions in the nucleus: in addition to its function as ribosome factory of the cells it is a multifunctional nuclear domain, and nucleolar activity is linked with several pathologies.
Since the RAAS exerts pro-inflammatory effects in addition to its function as an energy expenditure hormonal system, it is perfectly able to support the re-allocation of energy-rich fuels to the activated immune system.
In addition to its function as a positive regulator of NF-κB activation, it has been reported that the activity of NF-κB is controlled in a negative feedback loop by IκBζ expression.
In addition to its function as an iPod speaker dock, the XS-SR3 can also be used as computer speaker system.
Adipose tissue, in addition to its function as the major storage depot for TAG, is an active endocrine organ that senses metabolic signals and secretes hormones that profoundly influence hepatic lipid metabolism (Berg et al., 2001).
In addition to its function in the TGN, PKD is thought to play an important role in priming insulin vesicles for transport and immediate fusion (Li et al. 2004; Sumara et al. 2009).
In addition to its function of stimulating proliferation of human endothelial cells (Hu [1998]), Cu was shown to promote the differentiation of mesenchymal stem cells towards the osteogenic lineage (Rodriguez et al. [2002]).
