In addition to genotype imputation, established association intervals may be fine-mapped using dense, custom genotyping arrays.
In addition to average imputation qualities, it is also relevant to explore the distribution of INFO scores in each frequency bin.
In addition to the multiple imputation approach, we also performed analyses based on individuals with complete data.
In addition to its high imputation accuracy, the method is fast, owing to its deterministic nature and, therefore, it can easily be used in large data sets where the use of other methods is impractical.
> -wrap-foot> > -wrap-foot> > -wrap-foot> > -wrap-foot> The accuracy of imputation of rs681524 in all samples but from TwinsUK could be assessed in two samples from the G-EAR consortium (Carlantino and Friuli Venezia Giulia), subsets of which had whole-genome sequencing data available in addition to the original imputation (Table 6).
In addition to the 50 PROSPECT imputation operations for the CCGs, about 106 PROSPECT imputation operations for the CGs are observed per frame of 10 ms. Therefore, the number of CLSQ problems solved is less than one-third of that of MC MDT without CG selection.
Boichard et al. (2012) found that increased concentrations of SNPs at the ends of the chromosomes were helpful to improve imputation accuracy; it was an additional reason for BovineLD imputation to be more accurate than Bovine3K imputation, in addition to the increased overall density of the BovineLD chip compared with Bovine3K.
Here, we show that for the Mexican sample the major improvement associated with the use of the 1000 Genomes reference panel is the substantial increase in imputation efficacy, in addition to the larger number of imputed markers (Table 1).
In addition to a comprehensive comparison between imputation algorithms, we developed a web-based imputation tool--MissVIA to help researchers, who do not have good programming skills, to deal with missing values in their datasets.
18 In addition to a primary imputed analysis, we did sensitivity analyses on the original data and on imputed data created using different seeds and different imputation models.
