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No studies have explored the role of NSAIDs and/or SMT in addition to first line management for acute low back pain.
For the practitioner following the available guidelines the salient question is whether either of these two treatments are effective when delivered in addition to first line care universally endorsed in the low back pain treatment guidelines.
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15, 17, 18, 21– 23 Most trials compare dulaglutide to placebo in addition to first-line metformin therapy and have demonstrated promising A1c reductions for dulaglutide.
One of the centres also provides second-line antiretroviral treatment (ART) in addition to first-line regimens in the entire region.
Two phase III trials have assessed the role of monoclonal anti-EGFR antibody therapy in addition to first-line chemotherapy in the treatment of NSCLC (Pirker et al, 2009; Lynch et al, 2010).
The cost of a rapid diagnostic test is included in the model as a proxy cost for any diagnostic or co-treatment in addition to appropriate first line therapy [35].
The most important clinical question is whether NSAIDs and/or spinal manipulation are effective when delivered in addition to the first line of care.
Thus, in addition to surgery, first lines of defense are radiation therapy, anti-angiogenic agents and chemotherapy.
Dolutegravir also holds promise for better second-line ARV combinations, in addition to improving first-line treatment.
Thus, if genetic testing is to be offered in addition to a first-line smoking-cessation program, then it must result in enough new quitters (or reduced numbers of relapsers) in order to justify the costs.
Low-risk patients with pulmonary metastasis on chest X-ray received central nervous system prophylaxis with intrathecal MTX (MTX-IT) in addition to the first-line systemic MTX for possible occult cerebral metastases.
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