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The enzymatic parameters of LmPGM have been determined and compared with other PGMs from orthologous species in addition to elucidating its mechanism of action by docking the substrate, intermediate onto the active site.
Producing permanent, single-gene knock-outs of known DNA damage repair and response proteins and evaluating the effects on DNA repair and sensitivities to different PARPi will provide a better understanding of functional pathways involved in PARPi sensitivity in addition to elucidating differences among various classes of PARPi.
In addition to elucidating the evolution of the pore fluid geochemistry, the modeling was particularly helpful in understanding intriguing geophysical signatures (e.g. imaginary conductivity) that were otherwise difficult to interpret.
Here we will consider an electronic part of the microscopic dielectric permittivity created by and acting at interacting harmonic oscillators, with the goal of demonstrating that multi-atom interaction creates a kind of "VdW permittivity" for pairwise VdW forces in addition to elucidating a connection between VdW forces and the electronic part of microscopic dielectric permittivity.
In addition to elucidating the role of these two RAS-effector arms in cancer, this knowledge should provide insight into targeting RAS-driven tumors.
In addition to elucidating the neuro-anatomy of MTT [3], [14] [17], recent work has also documented how this capacity is influenced by aging, mental illness and injury to the brain [15], [18], [19].
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In addition to elucidate the downstream genes, there are many additional questions regarding the functions of the Teashirt proteins in carcinogenesis.
In addition, to elucidate the underlying molecular mechanisms of aggressive behaviors induced by sucrose consumption, we performed transcriptome analyses of brain tissues.
In addition to elucidate the counter-intuitive observations in experiments and computer simulations, our findings also highlight the role of defect-modulated morphology engineering that can be applied to design nanoscale material and structural applications.
In addition, to elucidate each intracellular mechanisms, the effects of an inhibitor of cAMP-dependent protein kinase, inhibitors of particulate or soluble guanylate cyclase on the each peptide-induced relaxation were investigated.
In addition, to elucidate the role of DCX in miR-29a induced axon branching, we specifically knocked down the endogenous DCX protein by RNAi (Fig. 4E and 4F).
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