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The synthesis and SAR in addition to docking studies of this class of inhibitors are described.
Since vesicle fusion is still impaired after overexpression of either SNAP-25 or a C-terminal peptide of synaptobrevin-2 we assumed that in addition to docking, Munc18-1 plays a critical function in downstream events leading to exocytosis (de Wit et al. 2009) (Fig. 3).
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In addition to docking-based IVS, there are several other computational methods that can be used for target identification, including ligand-based methods, binding site comparisons, protein ligand interaction fingerprints, and so on (Rognan 2010; Koutsoukas et al. 2011; Xie et al. 2011; Ma et al. 2013).
In addition to ensemble docking, we also docked ADP to the static equilibrated wild-type system.
Fans have vehemently defended Brady, and some even started an online crowdfunding page to pay the $1-million 1-millionteam was slapped with, in addition to being docked two drafineicks, in relathen teamhe scandal.
Hall: I would just say that in addition to the docking station, that alone signals the right message: This is a laptop replacement that can be your one machine.
From the analysis of the current knowledge, in addition to protein protein docking and secondary structure prediction results presented for the first time herein, a mechanistic framework emerges, where XPA builds the NER pre-incision complex in a modular fashion, as "beads on a string", where the protein protein interaction "beads", or modules, are interconnected by disordered link regions.
In addition to this, molecular docking study of synthesized compounds was also performed against selected targets of platelet aggregation and blood coagulation pathways to study the binding interactions which can provide an insight into the possible mechanism of action of these new molecules.
On the one hand, it is possible that the AAA5 mutations may, in addition to preventing linker docking, disrupt dynein's mechanochemical cycle and thus also prevent ATP hydrolysis.
However, in the developing nervous system, in addition to the unconventional DOCK-ELMO complexes, the conventional GEFs Trio and Sos are required [9], [58], [59], [60], [61].
As described in the patent, the new dock invention would allow for accessory charging in addition to the main iPhone docking, depending on the final configuration, and could offer induction-based charging methods for both accessories and future iPhones with that feature built-in.
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