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A large deletion in patients with X-linked retinoschisis (XLR, MIM 312700) was found to have disrupted at least the last coding exon of CDKL5, in addition to disruption of the RS1 gene (Huopaniemi et al. 2000).
In addition to disruption of the circadian rhythm in the L2 dendrite plasticity in per01 mutants, there were also observed changes in morphology of dendritic spines that were shorter in per01 mutants than in wild-type flies at ZT1 (Fig. 3).
In addition to disruption of protein degradation systems, activation of oxidative stress can induce P-S349.
In addition to disruption of genes by frameshift mutations, five PG1 genes were truncated by insertion sequences.
In addition to disruption of the coding sequence, myd88 mutant mRNA was expressed at a significantly lower level than mRNA of the wild-type allele.
Pandemics, like the recent 2009 H1N1 "swine flu" can cause a significant number of infections and death in addition to disruption of economic activity.
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The effect of NDGA on the filamentous actin cytoskeleton was comparable to that of cytochalasin D. However, in addition to the disruption of actin stress fibres, cytochalasin D also disrupted the circumferential actin filament network.
In addition to causing disruption in already established networks, overloading may also hinder the deployment of new ones.
In addition to livelihood disruption, the unweaving of the tightly-knit social fabric was a major factor that dissuaded families from relocating.
In addition to the disruption of the membrane phospholipid architecture, LP results in the formation of cytotoxic aldehyde-containing products that bind to cellular proteins and impair their normal functions.
In addition to possible disruption of MAPK signaling in schizophrenia and related conditions discussed above, nrg1 is a susceptibility gene for schizophrenia and expression of ErbB3 protein is defective in schizophrenia [53].
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