In addition to deleterious BRCA1/2 mutations in four HGSOC, BRCA1 methylation was detected in four of the 12 HGSOC and in the corresponding PDX (#11, 62, 48, 169 34.
The goal of B-SIFT is to enable prediction of activating mutations in addition to deleterious mutations that SIFT already predicts, and so we sought out a large-scale mutagenesis dataset with experimentally verified phenotypes for use in validation of B-SIFT's utility.
In addition to the deleterious effects of reduced diversity and low fiber diets discussed above, new research on the ketogenic diet shows that it alters the gut microbiomes of mice by increasing the mucus-degrading bacterium Akkermansia muciniphila a bug linked to both health and disease, meaning scientists don't really know yet what this diet could do.
The relevance of immune tolerance to gene therapy in Pompe disease indicates that hepatic expression might best be combined with nonhepatic expression, achieving the benefits of ubiquitous expression in addition to evading deleterious immune responses.
Thus, we propose that, in addition to the deleterious effects conferred by the absence of functional WASP, the patients' thymocytes expressing WASPΔVCA encounter a block to differentiation/ proliferation at the human counterpart of the murine DN3 stage (described above), and the block creates an unusually strong selective advantage for thymocytes bearing beneficial somatic mutations.
In addition to the deleterious effects of glucose and its derivatives, diabetic fibroblasts exhibit particular features.
However, in addition to the deleterious roles, TNF- α also exerts beneficial effects and mitigates inflammatory injury.
In addition to this deleterious mutation, several missense mutations were identified in the 192 familial samples, as presented in Table 2.
In addition to eliminating deleterious pathways, activating beneficial pathways may improve protein production, as shown that adding elongation factors to CFPS reactions increased protein synthesis rates and yields.
In addition to the deleterious direct effects on the person who smokes, smoking can also have indirect effects, for example, on the developing embryo or fetus.
As we can see, in addition to the deleterious effect on health, there is considerable economic and psychosocial morbidity associated with these disorders.
