Sentence examples for in addition to blockade from inspiring English sources

As such, targeting of Tie2 signaling in addition to blockade of VEGF may be of clinical relevance to overcome bevacizumab resistance in GBM patients.

Our previous work [ 31], showing a pro-proliferative role of RARγ suggests that, in addition to blockade of the RARα, the increased RARγ1 might have contributed to the cell increase in mammospheres treated with atRA and Ro41-5253.

Anti-OX40L monoclonal antibody (MAb) shows in vitro effector function; thus, in addition to blockade of signalling, it is also capable of lysing OX40L-expressing cells by antibody-dependent cell cytotoxicity and complement-dependent cytotoxicity.

Reconstitution of the PTEN C2 domain by adeno G4A C2 only led to the inhibition of both TGFβ‐induced FAK activation in H358ON cells expressing G4A G129E Δ C2 (Fig.  6i), TGFβ‐induced EMT (Fig.  6j), in addition to blockade of β‐catenin translocation from the cell membrane into the cytoplasm and nucleus (Fig.  6k,l).

Recently the VITAL study, a randomized controlled clinical trial with 281 type 2 diabetic patients with diabetic nephropathy, has shown that administration of a VDRA (paricalcitol) in addition to blockade of the RAAS causes sustained reduction in albuminuria and thereby potentially has clinically relevant renoprotective effects in patients with diabetic nephropathy (11).

Furthermore, it has recently been shown that administration of a VDRA in addition to blockade of the RAAS causes sustained albuminuria reduction and thereby has clinically relevant renoprotective effects in patients with CKD (23) (D. de Zeeuw, personal communication, American Society of Nephrology, 2009).

Our data suggest that PIK3CA mutation can be acquired during HER2 inhibitor treatment and that the presence of a PIK3CA mutation requires PI3K blockade in addition to HER2 blockade.

Consequently, similar efficacy of adalimumab and abatacept indicates a different mode of action of abatacept in addition to costimulation blockade.

One of the mechanisms by which monoclonal antibodies against TNFα mediate their therapeutic effects, in addition to TNFα blockade, may be through induction of apoptosis in monocytes and T cells by outside to inside signalling through transmembrane TNFα [ 48- 50].

In addition to rapid blockade of the IL-17 pathway, ixekizumab significantly suppressed 765 disease-related genes in week 2 biopsy specimens in the 150-mg group but not the placebo group.

The gp120-induced microglia production of chemokines, cytokines, NO and ROS were significantly reduced by a specific Kv1.3 blocker MgTx in addition to its blockade by broad spectrum Kv channel blockers 4-AP and TEA, suggesting an involvement of Kv1.3 in microglia production of neurotoxic substances and resultant neurotoxicty.